Abstract 11917: Reduced Left Atrial Strain Can Predict Higher Risk of Long-Term Major Adverse Cardiovascular Events Post-Myocardial Infarction: A Meta-Analysis

Abstract

Background: Risk stratification after acute myocardial infarction (AMI) is essential to plan management and reduce mortality. Deformation imaging of the left atrium (LA) has tremendous prognostic importance following AMI. LA dilation and larger LA volumes are associated with poor patient outcomes post-MI. LA strain is a more sensitive indicator that can be used to assess major adverse cardiovascular events (MACE) in post-MI patients, however, pooled data exploring its use in predicting long-term outcomes remain limited. Methods: A systematic literature search of PUBMED, Google Scholar, and SCOPUS databases was performed to identify studies reporting the association of MACE and LA strain. Data on the odds ratio (OR) with 95% confidence interval (CI) were collected and pooled to compute the pooled odds ratio using random-effects models. Heterogeneity was assessed using the I 2 test. I 2> 75% was considered a moderate inter-study variation. P<0.05 was considered statistically significant. Results: A total of 6 studies were included with 2931 AMI patients. Baseline characteristics of included studies are shown in Table 1 . The median follow-up in the studies ranged from 6 months to 4 years. Meta-analysis of included studies using random-effects models showed that reduced LA strain was predictive of long-term adverse cardiovascular events following MI (Pooled Odds ratio: 0.93 (0.90-0.96, p=<0.001, I 2 =48%) (Figure 1) . Conclusion: Reduced LA strain is associated with higher major adverse cardiovascular events in post-myocardial infarction patients and can be used in addition to LVEF to evaluate MACE.