Abstract 11893: The Impact of Statin Therapy on Survival Following Inpatient Cardiac Arrest

Abstract

Introduction: Over 200,000 hospitalized patients suffer cardiac arrest annually with a high morbidity and mortality following cardiopulmonary resuscitation (CPR). The aim of this study was to examine factors associated with survival post CPR in hospitalized patients. Hypothesis: Pre-arrest statin therapy is associated with improved survival. Methods: A retrospective analysis of consecutive hospitalized patients that underwent CPR between 4/2012 to 12/2013 at Beaumont Hospital. Patients with CPR perioperatively, in the setting of trauma, during pregnancy and postpartum were excluded, also patients or their surrogates who elected palliative care/hospice were excluded. Univariable and a step-down logistic regression multivariable analysis were performed. Results: Of 124 patients included in the study, 80 patients died, whereas 44 patients survived. Pre-arrest clinical factors and CPR characteristics associated with survival on univariable analysis were: History of PCI in 36.4% of survivors compared to 16.5% of those who did not survive (p=0.013). Hyperlipidemia was more common in survivors (68.2% versus 32.5%, p=0.001), as well as being on statins (76.7% versus 43%, p=0.0004). Those who did not survive were more likely to have active cancer (16.3% versus 2.3%, p=0.018), less likely to have a shockable rhythm (7.9% versus 27.9%, p=0.003), and more likely to have CPR ≥ 15 minutes (82.4% versus 19.5%, p<0.0001). On multivariable analysis, CPR duration and statin therapy were the only factors associated with survival. Those who did not survive were more likely to have CPR ≥ 15 minutes (Adjusted OR 18.08, 95% CI 6.5-50.5, p<0.001) and less likely to be on statin therapy before cardiac arrest ( Adjusted OR 0.29, 95% CI : 0.10-0.83 p= 0.021) with C-Statistic of 0.86. Conclusion: This study suggests that being on statin therapy is associated with high likelihood of survival following CPR. Further studies are needed to confirm this finding.