Abstract 11875: Cardiac Tumor: Multiparametric Myo-Mapping Study by Cardiac Magnetic Resonance in Cardiac Tumors

Abstract

Introduction: The characteristics and diagnostic value of T1, T2 mapping in cardiac tumors and myocardium are currently unknown. Hypothesis: We aim to explore tissue characteristics and diagnostic values of native T1, T2, and ECV values of left ventricular (LV) myocardium and cardiac tumors. Methods: In this prospective study, patients with suspected cardiac mass who underwent cardiac MRI between Nov 2011 and Mar 2021 were evaluated. Inclusion criteria were patients diagnosed with primary cardiac tumors and cardiac metastases based on surgical resection, biopsy, and comprehensive evaluations of medical history, imaging, and long-term follow-up. Patients were separated into primary benign, malignant cardiac tumors and cardiac metastases. Statistical analyses were performed using independent-samples t-test, Mann-Whitney U test, and receiver operating characteristic (ROC) analysis. Reproducibility was assessed by Bland-Altman analysis and coefficient of variation (CoV). Results: A total of 87 patients diagnosed as primary benign (n = 54), malignant cardiac tumors (n = 24), and cardiac metastases (n = 9), and 50 age and sex-matched healthy volunteers were included. Patients with primary malignant cardiac tumors (1362.5 ms ± 63.2) showed significantly higher myocardial T1 mapping values compared with patients with benign tumors (1259.7 ms ± 46.0), cardiac metastases (1287.6 ms ± 52.1), and with normal controls (1206.4 ms ± 44.0, all p value < 0.05). No significant difference in T2 mapping values were observed. Myocardial native T1 showed the highest diagnostic value between primary malignant and benign tumors (AUC: 0.917, cutoff value: 1300.2 ms) compared with myocardial T2 and ECV. Conclusions: This study indicated that while it is difficult to distinguish benign and malignant tumors based on mapping of cardiac tumors due to the high heterogeneity, myocardial T1 mapping value showed good diagnostic value between primary malignant and benign tumors.