Abstract 11865: Statin Decreases Risk of Dementia in Patients With Osteoarthritis: A Population-Based Study Abstract

Abstract

Emerging evidence suggested osteoarthritis is associated with increasing risk of dementia possibly because of accumulative age-related comorbidity and physical inactivity. Our study investigated whether statin use could reduce risk of dementia in patients with osteoarthritis. Methods Using a territory-wide health care database, we identified all eligible patients with osteoarthritis ( n = 146 933) from 2000 to 2010. Inverse probability of treatment weighting was used to adjust age, sex, comorbidities and concurrent medications between statin nonusers (n = 102 100) and statin users (n = 44 833). The adjusted hazard ratio was calculated using competing risk regression with Cox proportional-hazard model. Results Among all eligible patients, the mean age was 68.3 ± 13.4 years. The median follow-up was 5.6 years (interquartile range: 1.4-10.2 years), and 8247 (5.61%) patients developed dementia. Statin user (vs statin nonuser) was associated with a lower risk of dementia incidence [multivariable adjusted subdistribution hazard ratio (SHR) = 0.76 ; 95% confidence interval (CI), 0.72-0.80]. Among the subtypes of dementia, statin user (vs statin nonuser) was associated with a lower risk of Alzheimer disease [multivariable adjusted SHR = 0.67 ; 95% CI, 0.60-0.74] as well as vascular dementia [multivariable adjusted SHR = 0.88 ; 95% CI, 0.78-0.99]. This observation remains consistent in patients across all time-weighted LDL levels. Conclusions Our study suggested that statin use is associated with a lower risk of dementia in osteoarthritis patients, irrespective of time-weighted LDL level. In particular, statin user has a lower risk of Alzheimer disease and vascular dementia when compared with statin nonuser.