Abstract 11853: Prevalence and Correlates of Pre-Heart Failure Longitudinal Change in a Hispanics/latino Population-Based Study: Insights From the Echocardiographic Study of Latinos

Abstract

Background: Hispanic/Latinos have a high heart failure (HF) risk factor burden. Pre-HF is an entity known to progress to symptomatic HF. We aimed to characterize pre-HF prevalence and incidence among Hispanics/Latinos. Methods: The Echocardiographic Study of Latinos (Echo-SOL), a population-based sub-study of the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL), assessed cardiac parameters on 1,643 participants at baseline and serially 4.3 years later. Prevalent pre-HF was defined as the presence of any abnormal cardiac parameter (left ventricular (LV) ejection fraction <50%; absolute global longitudinal strain < 15%; grade 1 or more diasolic dysfunction; LV mass index >115 g/m 2 for men, >95 g/m 2 for women; or relative wall thickness >0.42). Incident pre-HF was defined among those without pre-HF at baseline. Sampling weights were utilized to account for the HCHS/SOL sampling design. Results: Among our study population (mean age: 56.4 years; 56% female), HF risk factors, including systolic blood pressure and glycosylated, worsened during follow-up. Significant worsening of cardiac parameters was evidenced from baseline to follow-up (p<0.01 for all parameters). The extent to which cardiac parameters changed during follow-up varied across Hispanic/Latinos background groups with Mexican and Dominican descent having the greatest worsening of LV systolic and diastolic function. Overall, the prevalence of pre-HF was 66.7% at baseline and the incidence of pre-HF during follow-up was 66.3%. Prevalent and incident pre-HF were seen more among those with HF risk factors (Figure 1) as well as with older age. Conclusions: Hispanic/Latinos in the Echo-SOL target population exhibited worsening of pre-HF characteristics over time, with important Hispanic/Latinos background differences. Incidence and prevalence of pre-HF are high and pre-HF is associated with HF risk factors in our target population.