Abstract #1185191: Acquired Generalized Lipodystrophy Presenting As Severe Insulin Resistance

Abstract

Roughly 100-150 cases are reported in the literature of acquired generalized lipodystrophy (AGL). This rare disorder is characterized by leptin deficiency resulting from low adipose mass and metabolic derangements such as hypertriglyceridemia and severe insulin resistance. These metabolic derangements lead to increased risk for pancreatitis, nonalcoholic fatty liver disease, and adverse cardiovascular events. The most common progression of AGL is onset of symptoms in childhood or adolescence with progression of complications into adulthood.