Abstract
Secretion of parathyroid hormone-related protein (PTHrP) accounts for up to 80% of cases with hypercalcemia of malignancy. It is most commonly associated with lung cancer, with a reported incidence up to 12.5% in those at advanced stages. While elevated PTHrP levels have been reported with all histologic types of lung cancer, it is rare in large cell carcinoma, with only 3 previously reported cases.
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