Abstract
Cushing’s syndrome is associated with multiple physical manifestations of hypercortisolism that impair patient quality of life. Improving physical manifestations of hypercortisolism is an important treatment goal for patients with Cushing’s disease (CD). In the Phase III LINC 3 study (NCT02180217), osilodrostat, a potent oral 11β-hydroxylase inhibitor, rapidly normalized and sustained control of mean urinary free cortisol (mUFC) in most patients with CD over a median treatment period of 130 weeks (W).
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