Abstract 1182: Ocimum gratissimum aqueous extract induces apoptotic signalling in human osteosarcoma cells.

Abstract

Abstract Osteosarcoma (Osteosarcoma) is a kind of bone cancer. Eighty percent of this tumor will be metastatic to the lungs or liver. Therefore, these patients generally need to use chemotherapy to improve disease and increase survival possibility. Recently, it has been reported that Ocimum gratissimum (OG) aqueous extract has anti-tumor activity. In this study, we detected the effect of OG extract on human bone cancer cell growth and metastasis. The results showed that the OG extract can inhibit cell growth and induce cell apoptosis in human bone cancer cells, but no effect in normal nerve cell. Therefore, we suggest that OG extract s may have anti-cancer ability, and can provide the use in the development of new anti-cancer drugs Figure . OGE effect on the cell growth in two osteosarcoma cells. Cell growth was determined 0∼3 or 0∼5 days after subculture using the MTT assay as described in Materials and Methods. Absorbance values obtained from the cells on day 0 after subculture were taken as 100%. Citation Format: Chien Chung Lin. Ocimum gratissimum aqueous extract induces apoptotic signalling in human osteosarcoma cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1182. doi:10.1158/1538-7445.AM2013-1182 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.