Abstract
Hashimoto’s encephalopathy (HE) is a rare disorder characterized by an autoimmune encephalopathy associated with elevated Thyroid Peroxidase (TPO) antibodies. Clinical features include neurocognitive dysfunction, psychiatric manifestations (paranoia, hallucinations, depression), sleep disturbance, seizures, and transient neurological deficits. The heterogeneity of it’s symptoms, and the broad differential of neuropsychiatric conditions make it a challenging diagnosis. Diagnosis is made in patients with an appropriate clinical picture, elevated TPO antibodies and response to treatment.
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