ABSTRACT 117

Abstract

Background and aims: Neurological outcome following cardiopulmonary arrest in children is poor and depends upon the quality and technique of CPR delivered. Active compression-decompression CPR (ACD-CPR) has been shown to result in improved hemodynamic outcomes, but neurological outcome has not yet been evaluated. We have developed a novel adhesive glove device (AGD) that allows us to achieve active compression-decompression CPR in neonate and pediatric piglet models of cardiac arrest. Aims: We hypothesized that ACD-CPR delivered by the adhesive glove device (AGD-CPR) results in better brain perfusion as compared to S-CPR and, thus, resulting in improved neurological outcome. Methods: Prospective, randomized, controlled survival animal study. Ten anesthetized & ventilated piglets of either sex (~12Kg) were randomized after 8 minutes of untreated VF to receive either Standard CPR (S-CPR) or AGD-CPR for 5 minutes. Neurologic outcome were determined using an already established multiple neurological deficit score by a veterinary neurologist at baseline and 24 hours after CPR. Data (mean±SD) were analyzed using Wilcoxon Mann-Whitney test; p-value ≤0.05 was considered significant. Results: AGD-CPR group exhibited better neurological outcome as compared to S-CPR group. Furthermore, four animals on the S-CPR group were blind, while all animals on the AGD-CPR group were visual.Table 1: Neurological outcome scoresConclusions: ACD-CPR delivered by our novel adhesive glove device (AGD-CPR) results in better neurological outcome in a swine model of cardiac arrest.