Abstract

Introduction: The number of patients with lower extremity artery disease (LEAD) continues to increase. Moreover, the volume of endovascular treatment (EVT) increases accordingly. On the other hand, malnutrition of LEAD patients is underestimated despite nutritional factors are potentially a correctable parameter. Geriatric nutritional risk index (GNRI), calculated from serum albumin and the components of the body mass index, is a simple nutritional screening method. However, it is not well known whether GNRI before EVT affects the prognosis of LEAD patients. Objective: We investigated whether GNRI before EVT affects the prognosis of LEAD patients Methods: This study was a single-center, retrospective analysis. Between January 2010 and December 2022, consecutive 130 patients underwent the first EVT for LEAD at our hospital. The patients were divided into two groups based on the median GNRI: GNRI ≥ 91 group (n = 68) and GNRI < 91 group (n = 62). The primary endpoint was all-cause death, and the secondary endpoints were major amputation and target lesion revascularization (TLR) after EVT. Results: During the follow-up, 67 patients died after EVT. All-cause mortality was significantly higher in GNRI<91 group (P < 0.001). However, major amputation and target lesion revascularization rates were not significantly different between the two groups. Conclusions: The GNRI before EVT was independently associated with mortality in patients with LEAD

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