Abstract 11621: Risk Factors for Cardiovascular (CV) Outcomes in Patients With Essential Thrombocythemia: An Analysis of the National Inpatient Sample (NIS)

Abstract

Introduction: Essential Thrombocythemia (ET) is a myeloproliferative neoplasm characterized by an overproduction of platelets in the bone marrow. Patients suffering from this condition are at a higher risk for CV complications. Studies have demonstrated a prothrombotic state in ET patients and a significant mortality rate stemming from thrombotic complications. However, data regarding the risk of hospitalization for CV events in patients with ET are scarce. Therefore, our objective was to identify risk factors for CV outcomes among patients with ET. Methods: We performed a retrospective analysis of the National Inpatient Sample (NIS) from 2016 to 2017. Patients included were at least 18 years of age and had an ICD-10 diagnosis of ET. To identify CV outcomes, an ICD-10 code for VTE, Stroke, ACS, or a Major Adverse Limb Event had to be present in the top three discharge diagnoses. We identified common chronic comorbidities and performed binary logistic regression to identify risk factors for hospitalizations due to CV outcomes. Those factors were then validated with the 2018 and 2019 NIS databases. Results: We identified a total of 234,225 (weighted) NIS patients with ET. The mean age was 59.72 years (SD = 18.679), and patients were predominantly female (57%). CV outcomes were present in 18,955 cases (8.10%). Significant predictors for CV outcomes among patients with ET included valvular disease (VHD) (odds ratio, 1.33 [95% CI, 1.23-1.43]; P<0.0001), peripheral vascular disease (PVD) (odds ratio, 1.97 [95% CI, 1.87-2.07]; P<0.0001), paralysis (odds ratio, 1.63 [95% CI, 1.54-1.73]; P<0.0001), and hypertension (HTN) (odds ratio, 1.36 [95% CI, 1.32-1.41]; P<0.0001). Upon re-testing with 237,345 (weighted) ET patients from the 2018 and 2019 NIS cohorts, significant risk factors included VHD (odds ratio, 1.99 [95% CI, 1.90-2.08]; P<0.001), PVD (odds ratio, 2.07 [95% CI, 1.98-2.16]; P<0.001), paralysis (odds ratio, 3.35 [95% CI, 3.21-3.49]; P<0.0001), and HTN (odds ratio, 1.68 [95% CI, 1.62-1.74]; P<0.001). Conclusion: Among patients with ET in the 2016-2019 NIS cohorts, VHD, PVD, HTN, and paralysis were associated with the greatest risk of CV outcomes. Patients hospitalized with ET may benefit from increased risk management in the setting of these comorbidities.