Abstract 11606: The Association Between Sarcoidosis and In-Hospital Outcomes Among African Americans With Acute Myocardial Infarction

Abstract

Introduction: Sarcoidosis (SD) has a higher prevalence among African Americans (AA). It is also associated with an increased risk of ischemic heart disease (IHD); however little is known of its effect on in-hospital outcomes after an acute myocardial infarction (AMI). Therefore, we sought to evaluate the association between SD and in-hospital outcomes among AA patients (pts). Methods: Using the National Inpatient Sample between 2005-2014, we evaluated admissions of AA presenting with AMI and a concurrent diagnosis of SD. We used propensity score matching in 1:3 fashion to create a comparison group of patients without SD based on age and comorbidities. Our primary outcome of interest was in-hospital mortality. Secondary outcomes were length of hospital stay and total cost of hospitalization. Results: We evaluated 416, 209 representative admissions of AA with AMI. Of these, we compared 2,647 had a concurrent diagnosis of SD to 7,942 pts without SD. The pt group with SD had mean age 58.1 years and were 61.5% female. When compared with the pts without SD, the pts with sarcoid were more likely to smoke (21.5% vs 19.5%, p=0.028), have liver failure (4.5% vs. 3.4%, p=0.007) and have a cancer diagnosis (2.8% vs. 2.1%, p=0.37), but less likely to have renal failure (25.0% vs 29.1%, p<0.001). When compared with the pts without SD, pts with SD had a significantly lower in-hospital mortality and cost of hospitalization ($46,593±69,981 vs $51,941±80,624, p=0.023). Conclusion: Although sarcoidosis is associated with increased risk of IHD, SD is associated with lower in-hospital mortality and lower cost of care in AA pts presenting with AMI. Further investigations are warranted to understand these outcomes. Table 1: Baseline characteristics of AA patients with AMI and sarcoidosis compared with a propensity-score matched cohort without sarcoidosis.