Abstract 11540: Charlson Comorbidity Index is an Effective Predictor of Hospital Outcomes in Takotsubo Cardiomyopathy

Abstract

Introduction: The Charlson Comorbidity Index (CCI) is a recognized predictor of clinical outcomes that has been studied in diverse clinical settings. In this study, we evaluate its utility for prediction of outcomes in Takotsubo cardiomyopathy. Methods: This is a retrospective cohort study using the 2018 Nationwide Inpatient Sample that included patients admitted with a primary diagnosis of Takotsubo syndrome. Outcomes were mortality, length of stay, total hospitalization charges, and cardiogenic shock. Multivariate regression analysis was performed adjusting for patient age, race, gender, severe sepsis, cardiogenic shock, tobacco use, atrial fibrillation, and other relevant comorbidities with a p-value <0.2 in univariate screen. Statistical analysis was performed using Stata 17.0. Results: A total of 7,970 weighted patients were hospitalized with Takotsubo syndrome, with a mean age of 66.5 years. Incidence of primary outcomes was gradually higher with an increasing Charlson Comorbidity Index. On multivariate regression analysis, each one-point increase in Charlson score was associated with 64% increased odds of inpatient mortality (odds ratio 1.64, p= 0.000). The odds of cardiogenic shock was also increased (odds ratio 1.24, p=0.000), as well as the mean length of stay and total hospitalization charges. Conclusions: The Charlson Comorbidity Index is an effective predictor of hospital outcomes in Takotsubo cardiomyopathy.