Abstract
Abstract In previous studies, glycolysis machinery has been identified as a regulating pathway in cancer cell. However, the role of glycolysis in oral squamous cell carcinoma (OSCC) progression is still largely unknown. Fructose-bisphosphate aldolase C (ALDOC), one of the key enzymes in glycolysis, expresses in OSCC patients and cell lines and detects by real-time quantitative RT-PCR. The functions of ALDOC were determined by gain and loss function approaches and the orthotopic animal model was performed. ALDOC mRNA and protein expression was significantly decreased in advanced migratory cell and negatively correlated with lymph node metastasis and advanced tumor TNM stage in OSCC patients. In conclusion, ALDOC plays as an OSCC prognosis marker clinically, and functions to suppress OSCC cell migration and invasion. ALDOC could be a potential therapeutic target to block OSCC progression. Citation Format: Yueju Li, Tse-Hung Huang, Been-Ren Lin, Cheng-Chi Chang. The regulatory effect of fructose-bisphosphate aldolase C in oral squamous cell carcinoma progression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1152. doi:10.1158/1538-7445.AM2015-1152
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