Abstract 11425: Left Ventricular Function and Coronary Artery Disease in Patients With and Without Diabetes. Long-term Follow-up - Revision-dm2 Trial

Abstract

Introduction: It is assumed that the left ventricular dysfunction due to ischemic cardiomyopathy is a major determinant of poor prognosis of survival when compared to preserved ventricular function. However, it is unknown the role of diabetes in long-term prognosis in this patient group compared to patients without diabetes. Hypothesis: To investigate whether the presence of diabetes affects the prognosis in ventricular function in long-term follow-up. Methods: We prospectively analyzed in a database, outpatients, previously submitted to percutaneous, surgical or clinical treatment. All patients had multivessel disease and LVEF measures. The events considered were overall mortality, nonfatal myocardial infarction, stroke and additional interventions. Results: From January 2009 to January 2010 were selected 918 consecutive patients, followed until May 2015. They were grouped into: G1, 266 diabetic patients with ventricular dysfunction, G2, 213 diabetic without dysfunction, G3, 213 patients without diabetes and without dysfunction and G4, 226 patients without diabetes and with dysfunction. The mortality rate was 21.6%, 6.1%, 4.2% and 10.6% for Groups 1, 2, 3 and 4 respectively. (p <0.001). The incidence of nonfatal myocardial infarction was 5.3%, 0.5%, 7.0% and 2.6% for groups 1, 2, 3 and 4 respectively (p <0.001). Stroke occurred at 0.40% 0.45%, 0.90% and 0.90% in groups 1, 2, 3 and 4 respectively (p = NS). Further interventions occurred in 3.8%, 11.7%, 10.3% and 2.6% for groups 1, 2, 3 and 4 respectively (p <0.001). Conclusion: In this sample, regardless of the treatment received, diabetes mellitus added higher risk of cardiovascular events in patients with coronary artery disease and left ventricular dysfunction.