Abstract 11381: Associations Between Serum and Dietary Omega-3 to Omega-6 Ratio and Cognitive Function in a Population of Community-Dwelling Japanese. -Tanushimaru Study-

Abstract

Introduction: Previous studies indicate that dietary omega-3 polyunsaturated fatty acids (PUFA) are modifiable risk factors for CVD and cognitive decline. This study aimed to investigate the association between serum and dietary omega-3/omega-6 PUFA ratio and cognitive function were measured in a general population. Hypothesis: We assessed the hypothesis that the serum and dietary omega-3/omega-6 PUFA ratio preserve a cognitive function. Method: A total of 976 residents (381 males, 595 females, mean age 62.6 years) underwent a physical examination, a nutrition survey and the mini-mental state examination as an evaluation of cognitive function in 2009 and followed up in 2018. Results: The serum omega-3/omega-6 ratio were significantly associated with age (p < 0.0001), sex (male, p <0.0001), MMSE ( p < 0.0001), LDL-c ( inversely, p < 0.01), and salt intake ( p < 0.05), using by multiple stepwise regression analysis. The dietary intake of proteins from fish ( p < 0.0001), trace elements, ( p < 0.01), vitamin D, B6, B12 ( p <0.0001), and salt ( p < 0.0001) showed dose dependent relationships with the serum omega-3/omega-6 ratio using analysis of covariance. Subjects were divided into 4 groups according to their progression of cognitive decline in 10 years. Serum omega-3/omega-6 ratio of group with normal cognitive function (NC) were significantly higher than those of group with cognitive decline (CD) (p < 0.05). However, dietary intakes of omega-3 and omega-6 PUFA were not significant. Interestingly, salt intakes in group with CD were higher than those in group with NC (p < 0.05). The logistic regression analysis revealed that salt intakes was associated with cognitive decline 10 years later after adjustments for confounding factors (odds ratio, 1.1; 95% C.I., 1.01-1.13; p = 0.01) In conclusion, the present study demonstrated that omega-3 PUFA may preserve a cognitive function and excessive intakes of salt may have an adverse effect on cognitive function.