Abstract 10823: Familial Hypercholesterolemia in the Brazilian Adult Population: Prevalence and Factors Associated According to the National Health Survey

Abstract

Introduction: Familial Hypercholesterolemia (FH) is a genetic dyslipidemia associated with premature coronary artery disease (CAD) and stroke, however it is underdiagnosed. The World Health Organization recognizes FH as a public health priority and recommends early diagnosis and treatment. In Brazil, the prevalence of FH in population representative studies is lacking. Objective: To estimate the prevalence and investigate factors associated with FH in the Brazilian adult population. Methods: A total of 8,521 adults over 18 years old from the National Health Survey (NHS, 2014-2015) were included in this cross-sectional analysis. FH was defined by the Dutch Lipid Clinic Network criteria (Dutch MEDPED). Possible FH was defined in individuals who scored 3 to 5 points: premature CAD (2 points) and/or cerebral disease (1 point), and LDL-Cholesterol (mg/dL): 155-189 (1 point), 190-249 (3 points), 250-329 (5 points), ≥330 (8 points). The prevalence of FH was estimated according to sociodemographic, lifestyle, and health conditions variables and differences were evaluated using the chi-square test (p ≤ 0,05). Results: The prevalence of possible FH was 0.96% and it was higher in women (1.22%; p = 0.04), individuals of 45 to 59 years (1.74%; p = 0.004), white race (1.13%; p = 0.05), illiterate or with incomplete elementary school (1.55%; p = 0.002), in the presence of hypertension (1.75%; p = 0.002), diabetes (1.85%; p = 0.02), total cholesterol ≥310 mg/dL (53.94%; p < 0.001), and poor/very poor health self-assessment (2.40%; p < 0.001). Conclusions: FH was frequently present in the Brazilian adult general population (1:104 individuals). The early identification of FH may contribute to reducing the burden of premature CAD in the country.