Abstract 10746: Association of Left Ventricular Relative Wall Thickness With Thromboembolism in Non-Valvular Atrial Fibrillation Patients With or Without Hypertension: The Fushimi Af Registry

Abstract

Introduction: Hypertension (HT) is the main cause of atrial fibrillation (AF) and left ventricular (LV) hypertrophy. Meanwhile, LV hypertrophy can be also the manifestation of some cardiomyopathies. We reported that increased LV relative wall thickness (RWT) was associated with the incidence of thromboembolism events (TE) in patients with non-valvular AF (NVAF). We investigated the association of RWT with TEs in NVAF patients with or without HT. Methods: In the Fushimi AF Registry, follow-up data were available for 4,489 patients. Of them, RWT values at enrollment were available for 3,408 patients with NVAF (with HT: n=2,159, without HT: n=1,249). We investigated the relationship between each RWT quartile and the incidence of TEs. Results: During the median follow-up period of 1,838 days, 297 TEs occurred. Regardless of the coexistence of HT, higher RWT groups had higher CHA 2 DS 2 -VASc score and higher HELT-E 2 S 2 score and the prescription of oral anticoagulants were comparable among the four groups. The incidence of TEs according to the groups stratified by each RWT quartile with or without HT is shown (Figure). In the multivariate analysis, higher RWT was independent predictors of TEs in the patients with or without HT (Table). The incidence rate of TEs were comparable between RWT>0.6 patients with HT and without HT (2.11 vs. 2.73% per patient-year, log-rank; p=0.67), whereas the patients with HT had higher CHA 2 DS 2 -VASc and HELT-E 2 S 2 scores. Conclusions: RWT was independently associated with the incidence of TEs among Japanese patients with NVAF regardless of the concomitance of HT.