Abstract 106: The inhibitory effects of baicalein on cell proliferation in breast cancer cells

Abstract

Abstract Baicalein is a naturally occurring substance found in certain herbaceous species such as Scutellaria baicalensis and Oroxylum indicum, as well more well-known species such as Thymus vulgaris (thyme). Classified as a flavonoid derivative, baicalein has been shown to inhibit cell proliferation by signaling apoptotic pathways in cell lines typically resistant to induced cell death. In this analysis, we have assessed cell viability by methylene blue staining and have shown that T47D breast cancer cells exhibit stunted proliferation patterns within 24 hours of exposure to baicalein at concentrations as low as 100 µM. Additionally, we have performed an analysis of the cell cycle by flow cytometry for which we have observed an arrest in the S phase, further indicating inhibited cell proliferation. Citation Format: Nicodemus C. Monear, Austin L. Kantola, Besa Xhabija. The inhibitory effects of baicalein on cell proliferation in breast cancer cells [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 106.