Abstract 10346: Peripheral Vascular Disease Hospitalizations with Cardiovascular Disease Risk and Major Adverse Cardiac and Cerebrovascular Events Occur at Increasingly Younger Age Across Two Nationwide Cohorts Selected 10-Years Apart

Abstract

Introduction: There have been increasing hospitalizations among young adults for peripheral vascular disease (PVD) in the last decade. We compared the mean age of young PVD admissions with cardiovascular comorbidities and major adverse cardiac and cerebrovascular events (MACCE) across two national cohorts 10-years apart. Methods: Two nationwide cohorts from 2007 and 2017 were analyzed for mean age at presentation with CVD risk factors and MACCE in young (18-44 years) PVD hospitalizations. Age at admission was reported as Mean± SD and compared between two groups using student’s t-test. Results: A total of 37,099 admissions in 2007 and 46,760 admissions in 2017 were identified for PVD among young adults. Total admissions increased from 0.4% to 0.5%.The 2017 cohort showed that non-elective PVD admissions occurred at significantly younger age (mean 35 vs 38 years) compared to 2007 cohort. Patients with PVD had comorbid risk factors including hypertension, diabetes mellitus, smoking, obesity, and congestive heart failure (CHF) with a mean age of 39±5 years at presentation in 2007 which decreased to 38±6 years for hypertension and diabetes, 36±6 years for smoking and 37±6 years for CHF and obesity (p<0.001) in 2017. Mean age for MACCE in PVD was 39±5 years in 2007 cohort which significantly reduced to 36±7 years in 2017 (p<0.001) (Table 1). Acute myocardial infarction, cardiogenic shock and PCI procedures were recorded at a younger age in 2017 PVD cohort vs. 2007 PVD cohort. Similarly, the 2017 PVD cohort included relatively younger patients experiencing ventricular tachyarrhythmias and stroke. Conclusions: This study from two young cohorts selected 10-years apart shows increasing trends in PVD hospitalizations occurring at a significantly younger age with associated cardiovascular comorbidities and MACCE in recent years. The link between young age and complicated/severe PVD admissions with frequent comorbidities should be further investigated.