Abstract 10101: Obstructive Sleep Apnea Syndrome Attenuates HDL Functions

Abstract

Background: High density lipoprotein (HDL) exerts anti-atherogenic functions including cholesterol efflux capacity and anti-oxidative activities. Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular disease via inflammation and oxidative stress. However, HDL functions in patients with OSA remains to be elucidated. We therefore investigated cholesterol efflux capacity and anti-oxidative activity in order to assess whether OSA would affect HDL functions. Methods and Results: A total of 116 OSA patients who underwent polysomnography tests from April 2017 to April 2019 were enrolled in this cross-sectional study. Blood samples were obtained at the next day of polysomnography test. We measured cholesterol efflux capacity in OSA patients and found that CEC was significantly lower in SAS groups (apnea hypoxia index (AHI)≧5) compared with non-SAS groups.(AHI<5)(1.06±0.15 vs 0.96±0.14 p=0.01) Among OSA parameters, minimal pulse oxygen saturation(minSpO2), a highly correlated parameter with AHI (r=-0.76 p<0.001), was found to be positively correlated with CEC (r=0.19 p=0.034) In multiple regression analysis , CEC was associated with minSpO2 independently of several clinical parameters including BMI, age, PON1, smoking, hypertension, dyslipidemia, diabetes mellitus, TC, logTG, HDL-C.(β=0.25 p=0.02) Further, CEC was inversely correlated with log hsCRP adjusted with the same model.(β=-0.25 p=0.01).With regard to anti-oxidative function, assessed by AAPH and PON1 activity, AHI or min SpO2 did not correlate with anti-oxidaitive activity by AAPH or PON1 activity. Conclusion: Obstructive sleep apnea syndrome attenuated cholesterol efflux capacity. Min SpO2 may be a good predictor of HDL dysfunction in OSA.