Abstract

Brown tumors are focal bone lesions formed by osteoclast and fibroblast proliferation with hemosiderin accumulation causing the brown color. They occur in 3% of secondary hyperparathyroidism and 2% of primary hyperparathyroidism (PHPT). In young patients with PHPT, it is prudent to obtain a thorough family history and consider genetic testing for multiple endocrine neoplasias (MEN), hyperparathyroid-jaw tumor (HPT-JT) syndrome, and familial isolated hyperparathyroidism (FIHP), since preferred surgical management may differ. We present a young man with bone pain who was found to have brown tumors caused by PHPT with negative genetic testing.

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