Abstract 029: Epidemiological Study Evaluating Uncontrolled Systolic Blood Pressure in Patients ≥ 50 Years With Hypertension, in Relation to Stroke Risk and Current Antihypertensive Treatment Strategies (systup) - Analysis of India Cohort

Abstract

Background: Uncontrolled hypertension (HT), a critical risk factor contributing to rising burden of stroke; 57% of all stroke deaths in India. Elevated mean systolic blood pressure (MSBP) accounts for most cases of uncontrolled HT. Aim: To assess systolic blood pressure (SBP) in patients ≥ 50 years with uncontrolled SBP, to illustrate correlation of MSBP with stroke risk (using Stroke Riskometer TM ), and the management of patients with uncontrolled SBP. Methods: SYSTUP, a non-interventional, observational study, recruited patients with age ≥50 years, with uncontrolled SBP (≥ 140 mm Hg), from 176 centers across India in real-world clinical setting. Descriptive statistics and Logistic regression analysis were used for risk calculation. Results: 3791 patients (men 60 %) - mean age 62 years, mean BMI 27 kg/m 2 and mean BP 157/90 mmHg. A significant positive correlation was found between MSBP and stroke risk. The likelihood of 5 year and 10 year stroke risk increased by approximately 4% with 1 mmHg increase in MSBP (P <.0001). MDBP did not exhibit any significant correlation with 5 year (P=0.242) and 10 year (P=0.8038) stroke risk. Comorbid diabetes was the main risk factor of 5 year stroke risk with odds ratio of 1.6. Majority of the patients were receiving angiotensin receptor blocker (ARB), irrespective of the risk categories - low, moderate, high, very high risk (Table). Conclusion: The SYSTUP India results show that elevated MSBP increases stroke risk in patients ≥ 50 years with uncontrolled HT mainly treated with ARB. These real-world clinical findings call for strengthening BP control in primary care to prevent stroke.