Absorption Study of Mozuku Fucoidan in Japanese Volunteers.

Kizuku Kadena,Masahiko Iha,Takeaki Nagamine,Makoto Tomori

doi:10.3390/md16080254

Abstract

We performed an oral administration study of fucoidan in 396 Japanese volunteers and investigated significant factors concerning the absorption of fucoidan. Urine samples were collected at 0, 3, 6, and 9 h after ingestion of 3 g of fucoidan. Fucoidan was detected in urine after ingestion in 385 out of 396 subjects. The maximum value (mean ± standard deviation (SD)) of urinary fucoidan was 332.3 ± 357.6 μg/gCr in subjects living in Okinawa prefecture, compared with 240.1 ± 302.4 μg/gCr in subjects living outside Okinawa. Compared with the estimated urinary excretion of fucoidan by place of residence, those of subjects living in Okinawa prefecture were significantly higher than those living outside Okinawa prefecture (p < 0.01). In addition, subjects living in Okinawa prefecture consumed significantly greater amounts of mozuku compared with those living outside Okinawa prefecture (p < 0.01). Multiple regression analysis showed that having Okinawa prefecture as a place of residence was a significant factor (p < 0.01) contributing to the estimated urinary excretion of fucoidan. Because the habit of eating mozuku was significantly higher (p < 0.01) in subjects living in Okinawa prefecture than in those living outside Okinawa prefecture, the habit of eating mozuku was speculated to be a factor in the absorption of fucoidan.

Highlights

According to the National Nutrition Survey in Japan, Japanese people eat about 14.3 g of seaweed per adult person daily [1], which includes konbu (Laminaria japonica), wakame (Undaria pinnatifida), hijiki (Hizikia fusiforme), nori (Porphyra tenera), and mozuku (Nemacystus decipiens)
Using this antibody and theshowed and the enzyme-linked immuno sorbentfrom assayOkinawa (ELISA) assay, we investigated intestinal absorption of mozuku fucoidan in rats, and assay, we investigated intestinal absorption of mozuku fucoidantract in rats, showed ingested that ingested fucoidan was absorbed across the intestinal andand taken up that by intestinal fucoidan was absorbed across the intestinal tract and taken up by intestinal macrophages and hepatic macrophages and hepatic Kupffer cells [23]
Eleven subjects who did not exhibit urinary fucoidan consisted of subjects living of urinary fucoidan varied widely among subjects, the values were ranked into groups from A to Ein

Summary

Introduction

According to the National Nutrition Survey in Japan, Japanese people eat about 14.3 g of seaweed per adult person daily [1], which includes konbu (Laminaria japonica), wakame (Undaria pinnatifida), hijiki (Hizikia fusiforme), nori (Porphyra tenera), and mozuku (Nemacystus decipiens). Okinawa mozuku is a species endemic to the Ryukyu archipelago, which is located between the southern limit (24◦ N) of the Yaeyama Islands in Okinawa prefecture and the northern limit (29◦ N) of Amami Island in Kagoshima prefecture (Figure 1) [2]. Okinawa mozuku contains about 1% fucoidan, and its structure was determined by Nagaoka et al, in 1999 [4]. Mozuku fucoidan is mainly composed of fucose-enriched sulfated polysaccharide with a molecular weight of 28.8 kDa (Figure 2) [4]. The clinical trials of fucoidan have been reported in patients with osteoarthritis and malignant tumors [11,12,13,14] and in

Methods

Results

Conclusion