Abstract
The absorption of inorganic sulfate after ingestion was investigated in rats. After oral administration of Na 2 35SO 4, 35S radioactivity waa measurable in plasma already after 15 min and its plasma concentration reached a peak after about 1.5–2 h. The 35S-radioactivity excreted in urine during 24 h after ingestion of Na 2 35SO 4 together with varying amounts of unlabelled Na 2SO 4 (0.25–5.0 mmol Na 2SO 4 per rat) indicated an almost complete absorption of inorganic sulfate from the gastrointestinal tract. Determination of the inorganic sulfate concentration in rat serum 2 h after oral administration of 5.0 mmol Na 2SO 4 revealed a three-fold increase in serum sulfate concentration. The data suggest a rapid and almost complete absorption of inorganic sulfate after oral administration in the rat. Its importance in relation to the sulfate availability for sulfate conjugation of drugs is discussed.
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