ABSORPTION OF RADIOACTIVE B_12 IN PATIENTS WITH PERNICIOUS ANEMIA AFTER LONG-TERM ORAL AND PARENTERAL THERAPY

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Article1 January 1960ABSORPTION OF RADIOACTIVE B12 IN PATIENTS WITH PERNICIOUS ANEMIA AFTER LONG-TERM ORAL AND PARENTERAL THERAPYP. J. FOUTS, M.D., F.A.C.P., O. M. HELMER, Ph.D., S. M. CHERNISH, M.D.P. J. FOUTS, M.D., F.A.C.P.Search for more papers by this author, O. M. HELMER, Ph.D.Search for more papers by this author, S. M. CHERNISH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-1-29 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe Hematology Research Clinic at the Marion County General Hospital in Indianapolis has been in continuous operation since the days when raw liver was used in the treatment of pernicious anemia. During this time more than 400 patients have been treated with oral and parenteral liver extracts, intrinsic factor preparations, and injectable B12 solutions. Some of the patients who have been followed continuously and are still reporting to the clinic have been on oral therapy for 29 years; others, on intrinsic factor preparations, parenteral liver or B12 solutions for as long as 26 to 27 years.During the last...Bibliography1. SchwartzLousMeulengracht MPE: Reduced effect of heterologous intrinsic factor, after prolonged oral treatment in pernicious anemia, Lancet 1: 751, 1957. CrossrefGoogle Scholar2. KristensenLundOhlsenPedersen HPJASJ: Maintenance therapy in pernicious anemia, controlled by determining vitamin B12 level in plasma, Lancet 1: 1266, 1957. Google Scholar3. Killander A: Oral treatment of pernicious anaemia with vitamin B12 and purified intrinsic factor. I. The value of serial estimation of the vitamin B12 levels of serum, Acta med. Scandinav. 160: 339, 1958. CrossrefMedlineGoogle Scholar4. 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KeuningArendsMandemaNieweg FJAEHO: Observations on the site of production of Castle's intrinsic factor in the rat, J. Lab. and Clin. Med. 53: 127, 1959. MedlineGoogle Scholar15. SchwartzLousMeulengracht MPE: Absorption of vitamin B12 in pernicious anemia. Defective absorption induced by prolonged oral treatment, Lancet 2: 1200, 1958. CrossrefMedlineGoogle Scholar16. BerlinBerlinBranteSjoberg HRGS: Studies on intrinsic factor and pernicious anemia. I. Oral uptake of vitamin B12 in pernicious anemia with increasing doses of an intrinsic factor concentrate, Scandinav. J. Clin. and Lab. Invest. 10: 278, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, Indiana*Received for publication May 16, 1959.Presented at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 22, 1959.From the Lilly Laboratory for Clinical Research and the Marion County General Hospital, Indianapolis, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIntrinsic FactorVitamin B12 and Intrinsic Factor 1 January 1960Volume 52, Issue 1Page: 29-43KeywordsAnemiaClinical laboratoriesHematology and oncologyHospitalsLiverMucous membranesPatientsPernicious anemiaResearch laboratoriesUrine Issue Published: 1 January 1960 PDF DownloadLoading ...