Absorption of Phenylbutazone from Enteric-Coated and Regular Tablets

Abstract

SummaryIn this study the concentrations in the blood of phenylbutazone with both enteric-coated and regular tablets were compared. The absorption of phenylbutazone from enteric-coated tablets took place as completely as from regular ones, but the maximum concentrations were reached later. In a long-term use of the tablets the concentrations leveled off within three days after the beginning of the experiment. Before that time the regular tablets resulted in higher concentrations. Enteric-coated tablets cannot be administered right after a meal because of an insufficient absorption, contrary to regular tablets that should be taken at mealtime or immediately after the meal.