Abstract
Abstract Intestinal absorption of thyroxine (T4) was estimated from the serum 125I/131I ratio after simultaneous administration of oral T4-125I and intravenous T4-131I. Studies in normal subjects showed that the form of the oral T4-l26I was of great importance to its absorption: When given in .01 g human serum albumin (HSA), absorption was 71.1% ±9.0 (sd); in .30 g HSA, 46.9±6.1; in gastric juice with carrier T4 but without HSA, 73.5 ±10.4; in saline, 50.0 ±7.5; and in capsules (with lactose) 41.7 ±9.0. With all techniques, maximum absorption percentages became constant after a few hours. Ultimate T4 absorption was unaffected by administration of epinephrine or methylglucamine. Studies in patients showed decreased absorption in those with malabsorption syndrome and in some cirrhotic individuals. Other cirrhotics had unusually high absorption percentages. Normal results were obtained in some cirrhotic patients, and in the other groups of patients studied, including 4 individuals thought to require large re...
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