Absorption of different oral dosage forms of oxycodone in the elderly: a cross-over clinical trial in patients undergoing cystoscopy

Abstract

To characterize the pharmacokinetics (PK) of oxycodone following intravenous injection and administration of three oral dosage forms (solution, capsule, and controlled-release tablet) in elderly patients (age 76-89years) undergoing cystoscopy. This was an open, randomized study with two sequences and two visits in 15 elderly patients. The patients were given intravenous injection (over 10min) of 5mg of oxycodone hydrochloride trihydrate. Oxycodone hydrochloride (5mg in all forms) was orally administered as a solution, a capsule, and a controlled-release tablet. Venous blood samples were collected up to 17h after oxycodone administration. Population PK parameters were calculated with NONMEM VI 2.0. For intravenous injection we calculated clearance, volume of distribution at steady state, and the half-life of elimination, and for oral dosage forms also the absolute bioavailability. Clearance of the intravenous injections was 28.9L/h; the volume of distribution at steady state and the half-life of elimination were 186L and 5.2h, respectively. The absolute bioavailability of oxycodone was 59% from oral solutions, 64% from capsules, and 55% from controlled-release tablets. Our results indicate that, in the elderly, the bioavailability of the three different oral dosage forms of oxycodone is fairly similar.