Absorption, LD50 and Effects of CoO, MgO and PbO Nanoparticles on Mice "Mus musculus"

Abstract

Metal oxide nanoparticles (NPs) are widely used in the world for different purposes. This is the first report on the LD50 and the effects of CoO, MgO and PbO NPs on mice. LD50 for acute and 30 day's chronic dosage of these metal oxide NPs was calculated. Our results showed that the acute (single dose exposure) LD50 for CoO is 7835 mg/kg, MgO is 3954 mg/kg and PbO is 14,677 mg/kg of body weight. Whereas, the LD50 for 30 days chronic dosage for CoO is 1066 mg/kg, MgO is 1315 mg/kg and PbO is 634.88 mg/kg of body weight. The NPs were deposited in different tissues of mice when exposed to acute and chronic dosages of all afore mentioned three different NPs. The NPs were maximally absorbed by the muscles on acute and chronic exposure to CoO, MgO as well as PbO NPs. The chronic exposure of CoO, PbO and MgO led to changes in behavior, body weight and organ index of the mice. Keywords: Absorption, Cobalt oxide NPs; LD50; Lead oxide NPs; Magnesium oxide NPs, Organ Index. Abbreviations: Nanoparticles (NPs), Cobalt oxide (CoO), Magnesium oxide (MgO), Lead oxide (PbO), body weight (bwt).