Absorption, Excretion, and Metabolism of p32-Labeled Metepa by Screw-Worm and Stable Flies

Abstract

The rate of absorption, excretion, and metabolism of P32labeled metepa by the screw-worm fly, Cochliomyia hominivorax (Coquerel), and the stable fly, Stomoxys calcitrans (L.), explain to a considerable extent the difference noted between the dosages required to sterilize these two species. On the basis of data obtained 6 hr after treatment, the screw-worm fly absorbed only half as much radiolabeled material in proportion to its size as the Stable fly. Excretion by the screw-worm fly was twice that of the stable fly, and metabolism by the stable fly was about twice as fast as for the screw-worm fly. The principal metabolite was phosphoric acid, and it occurred in greater quantity in the screw-worm fly than in the stable fly.