Abstract
Three studies were designed to determine the effects of various levels of tin (<1, ∼100, ∼200, ∼500 and ∼2000 µg tin/g diet) and zinc (∼15, ∼30, ∼52 µg zinc/g diet) on the metabolism of zinc by growing rats. Retention of zinc in tibia, kidney, liver and plasma was decreased significantly when rats consumed ≥500 µg tin/g diet. Tibia zinc levels were also sensitive to lower levels of dietary tin, i.e., even 100 µg tin/g diet when rats were fed 51.8 µg zinc/g diet. Apparent absorption of zinc was significantly less when rats were fed ∼200 or ∼500 µg tin/g diet rather than a control diet containing 15.8 µg zinc/g diet and significantly less when rats were fed ∼500 µg tin/g diet rather than ∼200 µg tin/g diet with 29.7 µg zinc/g diet. The effect of dietary tin on fecal excretion of endogenous zinc and true absorption of zinc seemed to be dependent on the dose. Rats fed ∼2000 µg tin/g diet lost significantly more zinc of endogenous origin in the feces than control animals. A significant decrease in true absorption of zinc was observed among those rats fed ∼500 µg tin/g diet with 29.7 µg zinc/g diet. Increased consumption of zinc resulted in decreased apparent absorption of zinc, increased losses of endogenous zinc in the feces, and decreased true absorption of zinc.
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