Abstract
Absorption, blood levels and skeletal uptake of fluorine (F) and calcium (Ca) from combinations of sodium monofluorophosphate (Na2PO3F) and calcium gluconate (CaGluc) were studied in rats under varying conditions. When Na2PO3F and CaGluc were ingested simultaneously in a ratio by weight F/Ca=1/50, absorption and skeletal uptake of F and Ca were parallel. This was partly due to the prolonged absorption of F under the influence of CaGluc. Hydrolysis of PO3F ions was weak in the stomach, nearly complete in the intestine and apparently complete in the blood plasma. Combined Na2PO3F-CaGluc ingestion gave a comparatively slow, moderate but prolonged elevation of the plasma F levels, while no influence on plasma Ca was found in normal rats. F and Ca absorption and skeletal uptake were increased in Ca-deficient rats and decreased in vitamin D2-intoxicated rats.
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