Absorption and Retention of Fluoride from Ingested Stannous Fluoride Dentifrice

Abstract

Absorption, excretion, and skeletal retention of fluoride were studied in rats fed daily 1.0mg. of fluoride from stannous fluoride and from a dentifrice containing stannous fluoride. Inhibiting effect of calcium ion accompanying ingested dentifrice upon absorption of fluoride from the intestinal tract was observed. Approximately 50.0 per cent of the ingested fluoride from stannous fluoride and 30.0 per cent of that from the dentifrice were absorbed. There was a steady increase in urinary excretion of fluoride as time progressed. The major portion of absorbed fluoride appeared to be retained in the skeleton. Femurs of rats receiving fluoride from stannous fluoride stored more fluoride than those receiving fluoride from dentifrice. The rats showed a diminishing ability to accumulate fluoride in their skeletons with increase in age.