Abstract
The concept of percutaneous coronary intervention with bioabsorbable stents has created interest because the need for stenting is temporary, and beyond the first few months there are disadvantages of a permanent implant. Conventional stents limit restenosis by holding back intimal flaps that have separated from deeper layers, and by preventing vessel recoil. The excessive healing response to stenting that contributes to restenosis could be abolished by coating stents with antiproliferative drugs. However, late-stent thrombosis sometimes occurs, probably because such drugs hinder the healing process that covers stent struts with endothelial cells. 1 Kotani J-I Awata M Nato S et al. Incomplete neointimal coverage of sirolimus-eluting stents: angioscopic findings. J Am Coll Cardiol. 2006; 47: 2108-2111 Crossref PubMed Scopus (436) Google Scholar , 2 Finn AV Joner M Nakazawa G et al. Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization. Circulation. 2007; 115: 2435-2441 Crossref PubMed Scopus (1148) Google Scholar Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trialThis study shows that biodegradable magnesium stents can achieve an immediate angiographic result similar to the result of other metal stents and can be safely degraded after 4 months. Modifications of stent characteristics with prolonged degradation and drug elution are currently in development. Full-Text PDF
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