Abstract
The absolute sterestructure of leptomycin B, an antitumor antibiotic and inhibitor of nuclear protein export, was firstly presumed as 1 having 4 S, 5 R, 10 R, 16 R, 18 S, 19 R, 20 S on the basis of NMR comparison with callystatin A ( 2) and then 1 was asymmetrically synthesized. The synthesized leptomycin B ( 1) was found identical with the authentic sample in HPLC and CD comparison as well as in other respects. This structural elucidation of the absolute stereostructure and total synthesis are the first example among the leptomycin family as Streptomyces metabolites.
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