Absolute quantification of high energy phosphate metabolites in normal, hypertrophied and failing human myocardium.

Abstract

For definitive conclusions, larger numbers of patients will have to be studied, but our preliminary results indicate that (1) ATP levels decline in heart failure but not in left ventricular hypertrophy and (2) phosphocreatine/ATP ratios underestimate the true changes in myocardial high-energy phosphate concentrations in chronically injured human myocardium.