Abstract
The absolute configurations of four resorcylic acid lactones (RALs), paecilomycins J-M (1-3 and 5), were assigned by Time-Dependent Density-Functional Theory (TDDFT) calculations of their electronic circular dichroism (CD) spectra. The previously reported structure 4 for paecilomycin M was found to be incorrect and should be changed to structure 5. Analysis of structure-spectrum relationship for this group of RALs suggested that V'-shape conformations give type I CD spectra (two negative Cotton effects around 300 and 260 nm, a positive Cotton effect around 220 nm) while V-shape conformations yield type II spectra (signs of three Cotton effects were opposite to those in type I).
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