Abstract
AbstractPhytochemical investigation of Parinari capensis (Chrysobalanaceae) led to the isolation of three diterpene lactones 1–3. The structures of these compounds have been established by NMR spectroscopy and X‐ray crystal‐structure analysis. Addition of bromine onto the exocyclic methylidene group of 1 yielded the brominated derivative 1‐Br. X‐Ray analysis of 1‐Br established unambiguously the absolute configuration, and 1 was then identified as the (4R, 9R)‐10‐hydroxy‐13‐methoxy‐9‐methyl‐15‐oxo‐20‐norkaur‐16‐en‐18‐oic acid γ‐lactone. Diterpenes 2 and 3 were identified as the C(13)‐demethoxylated and the C(13)‐demethylated derivatives of diterpene 1, respectively. Antifungal activity against Cladosporium cucumerinum was determined for 1–3.
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