Abstract
The absolute configuration of (–)-N,α-dimethyl-N-prop-2-ynylphenethylamine was determined using the isomorphous HCl and HBr salts. Beside X-ray analysis, the conformation of the free base, of the salt, and of the C-alkyl derivatives was studied by 1H and 13C n.m.r. techniques and potential-energy calculations. In the the solid state the extended conformer was observed, in solution the proportion of gauche-folded conformer increases with the bulkiness of R and decreases upon protonation of the nitrogen atom.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
