Abstract

AbstractVertical transmission of kuru, Creutzfeldt-Jakob disease, and scrapie has not been observed in 10 progeny of chimpanzees and monkeys born to parents which were either incubating or clinically ill with one of the diseases. Moreover, these 10 progeny have remained free of spongiform encephalopathy in spite of intensive postnatal contact with their affected parent(s). These data leave unanswered the mechanisms of viral transmission in the familial forms of Creutzfeldt-Jakob disease.

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