Abstract

ABSTRACT: Fresh E‐rosette positive lymphocytes from normal donors are not cytotoxic for the breast cancer‐derived target cell MDA‐157, although they do lyse other suspension and monolayer targets. E‐rosette positive cells from breast cancer patients in different stages of disease and from patients with benign breast disease also do not lyse MDA‐157. This remains true even when an HLA‐A or ‐B locus antigen is shared by effector and target cell. These data therefore provide no evidence for T cell sensitization in breast cancer patients.

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