Abstract
Background Poor prognosis in childhood neuroblastoma is associated with deletions of chromosome region 1p36 and di/tetraploid DNA content. Procedure Forty-six patients with histopathologically proven neuroblastoma were investigated for in vivo expression of somatostatin receptors (SR) by 111In-pentetreotide scintigraphy. All tumors were analyzed for cytometric DNA content and chromosome 1p36 integrity. Results SR expression was detected in 28 tumors (61%) and correlated with young age, localized clinical stage, and favorable outcome. Fourteen tumors showed deletion at chromosome 1p36, thirteen of which did not show SR expression (P < 0.001). A triploid DNA content was correlated with the presence of SR (23 of 25, P < 0.001). No tumor with deletion of chromosome 1p36 and di/tetra DNA content showed SR expression (χ2 = 29.88, d.o.f. = 2, P < 0.001). Conclusions We conclude that SR expression is related to genetic features of prognostic significance. This may be assessed with a minimally invasive scintigraphic method. Med. Pediatr. Oncol. 36:56–60, 2001. © 2001 Wiley-Liss, Inc.
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