Absence of secondary structure in a carbopeptoid tetramer of a trans-5-aminomethyl-tetrahydrofuran-2-carboxylate

Abstract

Whereas trimers and tetramers of β- C- d-arabinofuranosyl carbohydrate amino acids adopt well defined conformations based around a repeating β-turn like structure, stabilised by (i, i-2) inter-residue hydrogen bonds, there is no indication of any secondary structure in the tetramer of the epimeric α- C- d-arabinofuranosyl carbohydrate amino acid, where the C-2 and C-5 substituents of the tetrahydrofuran ring are trans to each other.