Abstract
Twelve adult female sheep were implanted stereotaxically with an array of 4–6 guide tubes positioned bilaterally above the hypothalamus. In addition, other sheep were implanted with cannulae to allow injections to be made into their lateral ventricles. Following recovery from surgery, body temperatures were monitored and bilateral (1 μl) injections were made into 92 sites throughout the hypothalamus. Prostaglandin E 1 (PGE 1 or E 2 (0.2–2.0 μg) did not cause fever on any occasion. Injection of 100 μg of PGE 1 into a lateral ventricle caused fever which reached a peak within 1 hr of injection. Injection of bacterial pyrogen (///S. abortus equi// or ///E. coli// pyrogen, 0.2 μg) into the same sites into which prostaglandin injections were made caused fever after some, but not all injections into the anterior hypothalamic/preoptic area (AH/POA). Thus, sheep may be able to develop fever without the central involvement of prostaglandin, or, if it does play a role, it may act within the brain at a site other than the AH/POA.
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