Abstract
When liver slices of Cs a and Cs b mice were incubated in vitro , they had similar catalase activities and equal rates of ethanol metabolism. While incubated liver homogenates and microsomes from Cs a mice oxidized ethanol and retained catalase activity, preparations from Cs b mice did not oxidize ethanol and lost all catalase activity. Addition of beef liver catalase restored ethanol oxidation by Cs b microsomes. The oxidations of aniline and aminopyrine proceeded at the same rate in Cs a and Cs b microsomes and were inhibited by ethanol. It is evident that (a) the microsomal drug-metabolizing pathway is not involved in ethanol oxidation, and (b) the postulation of a unique microsomal ethanol-oxidizing system (“MEOS”) that is independent of microsomal catalase is unwarranted.
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