ABSENCE OF EFFECT OF MULTIPLE INTRAPERITONEAL INJECTIONS ON CELL PROLIFERATION, AND ESTIMATION OF THE CELL CYCLE TIME IN THE EPITHELIUM OF THE OESOPHAGUS AND FORESTOMACH IN MICE, HAMSTERS AND RATS

Abstract

ABSTRACTCounts of labelled epithelial nuclei in mice given single or multiple injections of tritiated thymidine (to label cells synthesizing deoxyribonucleic acid), either alone or after 24 or 48 hr multiple injections of water, showed that multiple intraperitoneal injections did not disturb normal cell proliferation. The rate of cell proliferation was the same in the epithelium of the oesophagus and forestomach, and in these epithelia there was no difference between mice, hamsters and rats. Cell cycle times were estimated in these epithelia from the number of nuclei labelled in animals given single or multiple injections of tritiated thymidine.