Abstract
BackgroundThe pathophysiology of diabetic peripheral neuropathy (DPN) is complex and uncertain. A potential comorbidity in diabetes mellitus (DM) that may contribute to greater severity of DPN is a lipid disorder, such as with elevated cholesterol, low density lipoproteins or triglycerides. Oxidized low density lipoprotein (oxLDL) is a form of cholesterol that exerts direct toxic effects and contributes to pathogenicity through ligating a receptor called lectin-like receptor (LOX-1).MethodsWe examined plasma oxLDL levels in cohorts of patients with DPN with neuropathic pain (NeP), DPN patients without NeP, DM patients without DPN, patients with idiopathic peripheral neuropathy, and control subjects without DM or neuropathy. Our outcome measure was extent of oxLDL elevation, measured as fasting with Enzyme-Linked ImmunoSorbant Assay (ELISA) studies. Severity of diabetes was assessed using hemoglobin A1C measurements. Neuropathic severity was measured with the Utah Early Neuropathy Score (UENS). We hypothesized that DPN presence would be associated with oxLDL elevations.ResultsA total of 115 subjects (47 with DPN and NeP, 23 with DPN without NeP, 12 with diabetes only, 13 with idiopathic peripheral neuropathy, and 20 control subjects without diabetes or neuropathy) were studied. Duration of diabetes and diabetic glycemic measures were similar between populations with DM. Severity of DPN was similar between cohorts with DPN and NeP and DPN without NeP. Plasma oxLDL levels were similar between all cohorts, without any elevation in the presence of DM noted in any cohort with DM.ConclusionsoxLDL levels are not different in patients with DPN, and their lack of greater presence suggests that any pathogenic role in human DPN is likely limited.
Highlights
Diabetic polyneuropathy (DPN) is a common and disabling complication of human diabetes mellitus (DM) seen in up to 50% of patients, leading to sensory, motor and/ or autonomic dysfunction [1]
A total of 115 subjects participated, including 20 healthy control subjects (16 women), 13 subjects with idiopathic peripheral neuropathy (7 women), 12 subjects with non-complicated DM (DM only) (6 women), 23 sub diagnosed with DM with diabetic peripheral neuropathy (DPN) without pain (DPN-NoP) (7 women), and 47 subjects diagnosed with DM with DPN with persistent pain (DPN-P) (17 women) (Table 1)
We sought to determine if Oxidized low density lipoprotein (oxLDL) levels were heightened in patients with DM-mediated DPN and related to the presence of neuropathic pain in DPN-P patients
Summary
Diabetic polyneuropathy (DPN) is a common and disabling complication of human diabetes mellitus (DM) seen in up to 50% of patients, leading to sensory, motor and/ or autonomic dysfunction [1]. A common association with DM is the presence of a lipid disorder, or hyperlipidemia. This may include hypertriglyceridemia, elevated cholesterol, or may occur as part of a metabolic syndrome. This is clearly a risk factor for cerebrovascular and cardiovascular disease, hyperlipidemia may influence the peripheral nervous system, possibly correlating with progression of DPN [2]. A potential comorbidity in diabetes mellitus (DM) that may contribute to greater severity of DPN is a lipid disorder, such as with elevated cholesterol, low density lipoproteins or triglycerides. Oxidized low density lipoprotein (oxLDL) is a form of cholesterol that exerts direct toxic effects and contributes to pathogenicity through ligating a receptor called lectin-like receptor (LOX-1)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
